Jun 28, 2012 5:23 PM by CNN
WIMBLEDON, England - Rafael Nadal made his earliest Grand Slam exit since 2005 when he was overpowered Thursday by big-serving Lukas Rosol 6-7 (9), 6-4, 6-4, 2-6, 6-4 in the second round at Wimbledon.
Rosol, a 26-year-old Czech ranked No. 100, earned the biggest win of his career playing in Wimbledon's main draw for the first time. He lost each of the past five years in the first round of qualifying.
As the match stretched beyond dusk, the conclusion came with the retractable roof closed for the final set on Centre Court. The upset on tennis' biggest stage was no fluke: Rosol served brilliantly and repeatedly stepped instead the baseline to hit aggressive groundstrokes, while Nadal found himself pinned deep and on the defensive.
In other men's action, Andy Roddick advanced to the third round at a Grand Slam tournament for the first time this year when he beat Bjorn Phau 6-3, 7-6 (1), 6-3 Thursday at Wimbledon.
Roddick hit 13 aces, lost serve once and won 25 points at the net. The three-time Wimbledon runner-up will next play No. 7-seeded David Ferrer.
Roddick has struggled much of the year and he's seeded only 30th. But he won his fifth grass-court title last week as a wild card at Eastbourne, and he has swept all six sets this week.
Andy Murray managed to overcome Ivo Karlovic's hard serve for a 7-5, 6-7 (5), 6-2, 7-6 (4) win to reach the third round of Wimbledon.
Murray gave the home crowd at Centre Court some concern when he was broken in his first service game, but he held serve the rest of the way and broke Karlovic four times.
Murray again carries the hopes of the home nation that he can become the first British man since Fred Perry in 1936 to win Wimbledon. He's reached the semifinals at the All England Club the last three years.
A day after Prince Charles made his first visit to Wimbledon since 1970, Kate Middleton's sister Pippa sat in the Royal Box during the match.
Jo-Wilfried Tsonga of France overcame a sluggish start to beat Guillermo Garcia-Lopez in four sets and advance to the third round.
The fifth-seeded Tsonga, who defeated Roger Federer on his way to the semifinals at the All England Club last year, hit 40 winners in a 6-7 (3) 6-4 6-1 6-3 victory on Court 3.
The hard-hitting Tsonga never lost his serve and converted five of 10 break points against his Spanish opponent, who is ranked No. 92.
Tsonga will play Lukas Lacko of Slovakia in the next round.
Kei Nishikori became the first Japanese man in 17 years to reach the third round of Wimbledon by beating Florent Serra 6-3, 7-5, 6-2 on Thursday.
The 19th-seeded Nishikori had 45 winners to break Serra eight times and wrap up the win in 1 hour, 45 minutes on Court 17.
The last Japanese man to reach the round of 32 at Wimbledon was Shuzo Matsuoka in 1995. Nishikori said he trained with Matsuoka as a kid and still keeps in touch with him regularly. He said Matsuoka sent him an email after Thursday's match, and that "he's always helping me.''
Nishikori won his only ATP tour title in 2008 in Delray Beach but made two finals last year, including in Basel where he lost to Roger Federer.